Study of the Notch-Aromatic Hydrocarbon Receptor-Interleukin-22 Signaling Pathway and the Pathogenesis of Immune Thrombocytopenia

Objectives: Immune thrombocytopenia (ITP) is an acquired autoimmune bleeding disease characterized by thrombocytopenia. This review will examine the Notch-aromatic hydrocarbon receptor (AhR)-interleukin-22 (IL-22) signaling pathway regulatory mechanisms in ITP to generate ideas for pathogenesis and etiological investigation of disease. Mechanism: Studies had shown that abnormal imbalance immune cells factors associated with pathogenesis. The Notch-AhR-IL-22 disrupts microenvironment vivo, which contributes ITP. Findings Brief: Several studies have suggested may be mediated multiple pathways, such as Notch induces AhR increase direct secretion IL-22 from CD4+T or Notch-AhR differentiation into Th22 enhance expression. However, precise pathogenic are still unknown. Conclusions: complex, involved ITP, further research relationship between this needed.